Nearly every perfume you've ever worn is a blend: dozens, sometimes hundreds, of different aromatic materials layered together into top, heart, and base notes. In 2006, a German perfumer named Geza Schoen released one that broke that rule entirely, a fragrance made of exactly one ingredient.
Molecule 01, the debut release from Schoen's line Escentric Molecules, contains nothing but Iso E Super, a single synthetic compound used at high concentration with nothing blended in to soften, direct, or complicate it.
A molecule that doesn't exist anywhere in nature
Iso E Super itself isn't new. It was created in a lab at IFF back in 1973 and has no natural source at all. For over thirty years it played a supporting role in other people's formulas; Halston's first women's fragrance in 1975, for instance, used it at around 8% inside an otherwise fairly conventional rose-and-patchouli composition. Schoen's idea was to take an ingredient perfumers had only ever used as a background player and put it entirely, unapologetically center stage.
The result behaves strangely on skin. Because of the way Iso E Super interacts with the olfactory receptors that detect it, wearers often describe it seeming to fade and then reappear over the course of a day, rather than sitting at one constant strength, an effect perfumers call intermittence.
The perfume that smells different on every person
Because it's a single molecule interacting directly with an individual's own body chemistry and skin, rather than a complex blend masking those differences, Molecule 01 is famous for smelling noticeably different from one wearer to the next. It's a genuinely personal fragrance in a way blended perfumes rarely manage to be.